Rosadan 0.75% Gel.45g(Metronidazole 甲硝唑凝胶) - 痤疮药物...

来自 : www.120ty.net/bencan...php?fid 发布时间：2021-03-25

临床药理学
对10名酒渣鼻患者的面部局部给药1克（甲硝唑）凝胶（7.5毫克甲硝唑）的生物利用度研究显示，一名患者的最高血清浓度为66毫克/毫升。该浓度比单个250mg口服片剂提供的浓度低约100倍。 在所有患者的大多数时间点，血清甲硝唑浓度均低于测定的可检测限。三名患者在任何时间点均未检测到甲硝唑的血清浓度。临床研究期间凝胶的平均剂量为600毫克，代表每次应用4.5毫克甲硝唑。 因此，在正常使用水平下，该制剂提供最低的甲硝唑血清浓度。Rosatan（甲硝唑）凝胶在治疗酒渣鼻中的作用机制尚不清楚，但似乎具有抗炎作用。
适应症和用途
Rosatan （甲硝唑）凝胶可局部用于治疗酒渣鼻的炎症性丘疹和脓疱。
剂量和给药
每天早上和晚上两次将Rosadan（甲硝唑）凝胶薄膜涂抹并擦洗至整个患处。
在使用Rosadan （甲硝唑）凝胶之前，应清洁待处理区域。 在使用Rosadan （甲硝唑）凝胶后，患者可以使用化妆品。
禁忌症
具有甲硝唑，对羟基苯甲酸酯或其他配方成分过敏史的个人禁用Rosadan（甲硝唑）凝胶。
包装供应方式
Rosadan（甲硝唑）凝胶USP，0.75％装在45克试管中NDC 43538-182-45
储存条件
存放在20 -25 C（68 -77 F）[请参阅USP控制的室温]。
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ROSADAN 0.75 % GEL 45GM METRONIDAZOLE MEDIMETRIKS PHARMA INC. 43538018245
使用以原处方为准；
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=99eaa138-0cfa-45e1-abbf-a88271707979
Rosadan(Metronidazole Gel USP, 0.75%)Gel and Rosadan(Metronidazole Topical Cream, 0.75%) Cream
Indicated for the treatment of inflammatory papules and pustules of rosacea
Specially developed formulas ideal for treating the face
Elegant formulations spread easily
Rosadan Gel is engineered for patients with oily skin
Rosadan Cream is engineered for patients who may benefit from additional emollients
Rosadan Gel Kit Includes:
Rehyla Wash
Unique cosmetic wash containing hyaluronic acid, chamomile and niacinamide
Gentle formula developed for patients with sensitive, irritated skin
Dermatologist-tested formulation is non-irritating
Dye, fragrance, paraben and sulfate free
May help reduce the appearance of redness
Offers unique conditioning properties
IMPORTANT SAFETY INFORMATION
Rosadan (Metronidazole Topical Cream, 0.75%) and Rosadan (Metronidazole Gel USP, 0.75%) are indicated for topical application in the treatment of inflammatory papules and pustules of rosacea. The following adverse events have been reported with the topical use of metronidazole: burning, stinging, erythema, skin irritation, pruritis and worsening of rosacea. Additional adverse experiences include dryness, transient redness, metallic taste, tingling or numbness of extremities and nausea. Rosadan Cream and Rosadan Gel are contraindicated in individuals with a history of hypersensitivity to metronidazole or any other ingredients in this formulation. Not for ophthalmic or vaginal use.